Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Rhizopus arrhizus ICU, Aplastic Anemia Eyes, Gastrointestinal tract, Lungs, Paranasal sinus(es) Amphotericin B lipid complex Amphotericin B lipid complex, Posaconazole, Itraconazole Resection of the terminal ileum and cecum Complete Response Yes 2010
Rhizopus arrhizus Chemotherapy, ICU, Neutropenia Deep soft tissues Amphotericin B lipid complex, Micafungin Amphotericin B lipid complex, Micafungin Debridement Complete Response Yes 2011
Rhizopus arrhizus Chemotherapy, Chronic pulmonary disease, Diabetes Mellitus, Radiotherapy Skin and Deep soft tissue Amphotericin B liposomal Amphotericin B liposomal - Complete Response No 2013
Rhizopus arrhizus Diabetes Mellitus Bone, CNS, Paranasal sinuses, Vessels, Disseminated Amphotericin B liposomal Amphotericin B liposomal Right medial maxillectomy and anterior ethmoidectomy Stable Disease Yes 2015
Rhizopus arrhizus Chemotherapy, Neutropenia Bone, Skin and Deep soft tissue Caspofungin Caspofungin Craneotomy with bone and soft tissue resection Complete Response No 2014
Culture available Rhizopus arrhizus Diabetes mellitus, ICU CNS, Eyes Caspofungin, Fluconazole Liposomal amphotericin B Debridement Deterioration or failure No 2010
Rhizopus arrhizus Diabetes mellitus, HSCT, ICU Bones, Eyes, Paranasal sinus(es) Fluconazole Caspofungin, Liposomal amphotericin B, Posaconazole Decompression of left orbita and debridement of leftsided sinusitis Deterioration or failure No 2010
Rhizopus arrhizus Chemotherapy, HSCT, ICU, Neutropenia Lungs, Paranasal sinus(es) Micafungin, Amphotericin B lipid complex Amphotericin B lipid complex Functional endoscopic sinus surgery (FESS) Deterioration or failure No 2012
Rhizopus arrhizus Chemotherapy, HSCT-Allogeneic Paranasal sinuses Posaconazole Posaconazole Osteoplastic surgery of the maxillary sinus Complete Response No 2012
Rhizopus arrhizus Chemotherapy, Neutropenia Lung Voriconazole Voriconazole - Partial Response Yes 2015
Culture available Rhizopus arrhizus HSCT, ICU Deep soft tissues, Lungs, Paranasal sinus(es), Skin Voriconazole Posaconazole, Other Radical resection of right lower jaw, orbitotomy, nasal ablation Deterioration or failure No 2008
Rhizopus arrhizus Diabetes mellitus, ICU Bones, Paranasal sinus(es) - Posaconazole Bone resection Complete Response Yes 2009
Rhizopus arrhizus HSCT, ICU Lungs - Liposomal amphotericin B, Terbinafine, Voriconazole - Deterioration or failure No 2011
Culture available Rhizopus arrhizus ICU, Ulcerative Colitis Bones, CNS, Paranasal sinus(es) - Liposomal amphotericin B, Posaconazole, Isavuconazole Emergency surgical resection Complete Response Yes 2008
Rhizopus arrhizus Chronic renal disease, ICU CNS, Paranasal sinus(es) - Liposomal amphotericin B, Posaconazole Cerebral abscess surgery and surgery of the paranasal sinuses Complete Response Yes 2011
Rhizopus arrhizus Chronic renal disease, Diabetes mellitus, ICU Paranasal sinus(es) - Liposomal amphotericin B Functional endoscopic sinus surgery (FESS) Complete Response Yes 2015
Culture available Rhizopus arrhizus ICU, Major surgery Lungs - Liposomal amphotericin B - Deterioration or failure No 2012
Rhizopus arrhizus HSCT, ICU Paranasal sinus(es) - Liposomal amphotericin B - Unknown Yes 2012
Rhizopus arrhizus Diabetes mellitus, ICU, SOT Eyes, Paranasal sinus(es), Skin - Liposomal amphotericin B - Stable Disease No 2013
Rhizopus arrhizus ICU, ANA-positive mouth ulcers CNS, Eyes, Paranasal sinus(es) - Amphotericin B deoxycholate - Deterioration or failure No 2013
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany