Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Mucor spp. or Rhizopus spp. Cancer (AML), Chemotherapy, Neutropenia Joint, Lungs, Disseminated Liposomal amphotericin B, Posaconazole Unknown No 2017
Rhizopus microsporus var. rhizopodiformis Cancer Other (Multiple Myeloma), Corticosteroids, Immunosuppression, Chemotherapy, Chronic cardiovascular disease, Hematopoietic stem cell transplantation (HSCT), Hematopoietic stem cell transplantation (HSCT) Gastrointestinal tract, Gastrointestinal tract Liposomal amphotericin B Liposomal amphotericin B Partial gastrectomy + small intestine resection with digestive haemorrhage and necrotic lesions in a context of grade 3 digestive GVHD Deterioration or failure No 2005
Rhizopus microsporus Corticosteroids, Immunosuppression, Major surgery, Solid organ transplantation, ICU Gastrointestinal tract Voriconazole Small intestine partial resection Deterioration or failure No 2013
Rhizopus arrhizus Corticosteroids, Immunosuppression, Chronic renal disease, Solid organ transplantation CNS, Paranasal sinus(es) Liposomal amphotericin B, Micafungin, Posaconazole Several debridements Deterioration or failure No 2017
Rhizopus microsporus Trauma Deep soft tissues Liposomal amphotericin B, Caspofungin, Posaconazole 22 surgeries Complete Response Yes 2010
Rhizopus arrhizus Cancer (ALL), Corticosteroids, Immunosuppression, Chemotherapy, Neutropenia Lungs Amphotericin B lipid complex, Posaconazole Complete Response No 2015
Rhizopus spp. Cancer (Lymphoma), Immunosuppression, Chemotherapy, Neutropenia, ICU Lungs Liposomal amphotericin B, Posaconazole, Caspofungin Deterioration or failure No 2012
Rhizopus arrhizus Immunosuppression, Alcoholism, Chronic liver disease, Solid organ transplantation Paranasal sinus(es) Voriconazole Liposomal amphotericin B Deterioration or failure No 2012
Rhizopus spp. Cancer (AML), Chemotherapy, Neutropenia, ICU Gastrointestinal tract Caspofungin Unknown No 2017
Rhizopus arrhizus Cancer (AML), Corticosteroids, Immunosuppression, Chemotherapy, Chronic cardiovascular disease, Neutropenia, ICU Paranasal sinus(es) Liposomal amphotericin B, Posaconazole Liposomal amphotericin B Ethmoidectomy associated with a right middle meatotomy and excision of the right middle turbinate Unknown No 2012
Rhizopus spp. Cancer (AML), Chemotherapy, Hematopoietic stem cell transplantation (HSCT) Lungs Voriconazole, Posaconazole, Isavuconazole Partial Response Yes 2016
Rhizopus microsporus Cancer (Lymphoma), Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT) Gastrointestinal tract Liposomal amphotericin B Unknown No 2014
Rhizopus spp. Chronic cardiovascular disease, Chronic renal disease, Diabetes mellitus, ICU Heart, Lungs, Spleen, Disseminated Micafungin Deterioration or failure No 2015
Rhizopus spp. Diabetes mellitus CNS, Paranasal sinus(es), Left Orbita, pre-pontine cysterne, dural enhancement, Disseminated Liposomal amphotericin B, Micafungin Liposomal amphotericin B, Posaconazole Unknown Yes 2016
Rhizopus microsporus Cancer (ALL), Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT), Neutropenia Deep soft tissues Liposomal amphotericin B Deterioration or failure No 2007
Rhizopus spp. Cancer (AML), Chemotherapy Eyes, Paranasal sinus(es), Disseminated Posaconazole, Liposomal amphotericin B Liposomal amphotericin B, Posaconazole, Micafungin Local debridements Complete Response Yes 2015
Rhizopus microsporus Diabetes mellitus, Trauma Deep soft tissues Liposomal amphotericin B, Posaconazole Patient had 9 x surgeries Complete Response Yes 2008
Rhizopus spp. Trauma, ICU Gastrointestinal tract, PeritoneumGastrointestinal tract, Disseminated Micafungin, Liposomal amphotericin B Liposomal amphotericin B, Posaconazole, Debridement drainage Deterioration or failure No 2014
Rhizopus arrhizus Diabetes mellitus Paranasal sinus(es), Vessels Liposomal amphotericin B Excision maxillary sinuses Unknown No 2011
Rhizopus microsporus Cancer (ALL), Corticosteroids, Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT) Lungs Caspofungin, Liposomal amphotericin B, Posaconazole Posaconazole, Liposomal amphotericin B The patient underwent a thoracotomy and resection of the middle lobe on day -7, followed by resection of the RLL on day 37 Stable Disease No 2014
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany