Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Last Observed
Rhizopus microsporus Chemotherapy, HSCT, ICU, Neutropenia Bones, Paranasal sinus(es), alveolar process Amphotericin B lipid complex, Posaconazole solution subtotal resection of maxilla and bony palate Complete Response Yes 2010
Culture available Rhizopus arrhizus Diabetes mellitus, ICU Lungs Unknown Yes 2009
Rhizopus arrhizus Diabetes mellitus, ICU Bones, Paranasal sinus(es) Posaconazole solution Posaconazole solution bone resection maxilla Complete Response Yes 2010
Culture available Rhizopus arrhizus HSCT, ICU Deep soft tissues, Lungs, Paranasal sinus(es), Skin Voriconazole Posaconazole solution radical resection of right lower jaw, orbitotomy, nasal ablation Deterioration or failure No 2008
Rhizopus microsporus Chemotherapy, ICU Deep soft tissues, Lungs, Skin Liposomal amphotericin B, Posaconazole solution Surgical catheter removal Complete Response No 2009
Rhizopus homothallicus ICU, No risk factor identified Deep soft tissues, Skin Debridement of the ulcer was done Complete Response Yes 2008
Culture available Rhizopus microsporus Chronic pulmonary disease, Diabetes mellitus, HSCT, ICU Lungs Posaconazole solution, Liposomal amphotericin B Deterioration or failure No 2005
Rhizopus sp. Chemotherapy, ICU Lungs Liposomal amphotericin B Partial Response No 2007
Rhizopus microsporus HSCT, ICU Lungs Caspofungin Liposomal amphotericin B, Posaconazole solution Deterioration or failure No 2008
Culture available Rhizopus microsporus HSCT, ICU CNS, Kidneys, Liver, Lungs Posaconazole solution, Caspofungin, Anidulafungin, Voriconazole Deterioration or failure No 2008
Rhizopus arrhizus ICU, Other: Aplastic Anemia Eyes, Gastrointestinal tract, Lungs, Paranasal sinus(es) Amphotericin B lipid complex Amphotericin B lipid complex, Posaconazole solution, Itraconazole Resection of the terminal ileum and cecum Partial Response Yes 2011
Rhizopus arrhizus Chemotherapy, Chronic pulmonary disease, HSCT, ICU, Neutropenia, Bronchangitis obliterans like bronchial Disease Deep soft tissues, Liver, Lungs, Peritoneum, Spleen Deterioration or failure No 2010
Culture available Rhizopus arrhizus Diabetes mellitus, ICU, Trauma Deep soft tissues, Skin Amphotericin B deoxycholate Wounddebridement Deterioration or failure No 2006
Rhizopus sp. Chronic renal disease, Diabetes mellitus, ICU, SOT Paranasal sinus(es) Amphotericin B lipid complex, Posaconazole solution ENDOSCOPIC ENDONASAL DÉBRIDEMENT OF INVASIVE FUNGAL SINUSITIS, MEDIAL MAXILLECTOMY, ANTERIOR AND PO Complete Response Yes 2010
Culture available Rhizopus arrhizus Diabetes mellitus, ICU CNS, Eyes Caspofungin, Fluconazole Liposomal amphotericin B debridement Deterioration or failure No 2010
Rhizopus sp. Chemotherapy, ICU, Neutropenia Lungs Posaconazole solution Posaconazole solution extraanatomical resection of mycetoma in left lung (S3) Complete Response No 2009
Culture available Rhizopus arrhizus Chronic renal disease, Diabetes mellitus, ICU, SOT Lungs Caspofungin Deterioration or failure No 2010
Rhizopus microsporus Chemotherapy, HSCT, ICU, Neutropenia Lungs Caspofungin, Amphotericin B lipid complex Deterioration or failure No 2010
Rhizopus sp. Chemotherapy, ICU, Neutropenia Deep soft tissues, Lungs Voriconazole, Liposomal amphotericin B Liposomal amphotericin B, Posaconazole solution excision of lession on left antebrachium Stable Disease No 2010
Rhizopus sp. Chemotherapy, ICU, Major surgery, Neutropenia Bones, Deep soft tissues, Gastrointestinal tract, Lungs Amphotericin B lipid complex Amphotericin B lipid complex, Caspofungin pulmonectomia l.sin. and sutura of oesophagus Complete Response Yes 2011
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany