Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Lomentospora prolificans ICU, Major surgery Lungs, Peritoneum, Skin Fluconazole Voriconazole, Caspofungin, Liposomal amphotericin B Deterioration or failure No 2008
Culture available Lomentospora prolificans Corticosteroids, Immunosuppression, Cancer (AML), Hematopoietic stem cell transplantation (HSCT) Kidneys, Lungs, Other: Myokard Caspofungin Voriconazole, Terbinafine Deterioration or failure No 2008
Culture available Lomentospora prolificans No risk factor identified Paranasal sinus(es) Itraconazole Surgical debridement of sinus nasalis Complete Response Yes 2006
Lomentospora prolificans Corticosteroids, Cancer (Lymphoma), Chemotherapy, Neutropenia Blood Itraconazole Deterioration or failure No 2015
Culture available Lomentospora prolificans Cancer (AML), Cancer Other (Colorectar cancer), Chemotherapy, Neutropenia, Colorectal Cancer Blood, CNS, Eye, Disseminated Amphotericin B liposomal Caspofungin, Voriconazole, Anidulafungin Vitrectomy right eye Progression No 2016
Lomentospora prolificans Other: Contact lenses use Eyes Fluconazole, Voriconazole, Amphotericin B deoxycholate Voriconazole, Amphotericin B deoxycholate, Amphotericin B liposomal, Other Enucleation of the left eye Complete Response Yes 2016
Lomentospora prolificans Trauma Bones, Joint Voriconazole, Other Extense debridement for cleaning, with medium arthrotomy Complete Response Yes 2014
Lomentospora prolificans Cancer (ALL), Chemotherapy, Neutropenia, ICU, Other: Post-chemotherapy aplasia with infectious enterocolitis Gastrointestinal tract, Kidneys, Disseminated Amphotericin B liposomal, Voriconazole Progression No 2015
Lomentospora prolificans Corticosteroids, Immunosupression, Cancer (AML), Chemotherapy, Neutropenia Blood, Disseminated Amphotericin B liposomal Progression No 2017
Culture available Lomentospora prolificans Cancer (AML), Hematopoietic stem cell transplantation (HSCT) - Allogeneic, Chemotherapy Blood, Disseminated Caspofungin Progression No 2016
Lomentospora prolificans Chronic cardiovascular disease Eyes Fluconazole, Voriconazole Other, Micafungin, Voriconazole Left eye enucliation Partial Response Yes 2015
Lomentospora prolificans Corticosteroids, Immunosupression, Cancer (Lymphoma), Hematopoietic stem cell transplantation (HSCT) - Autologous, Chemotherapy, Neutropenia Blood Fluconazole, Micafungin Amphotericin B liposomal Unknown No 2015
Lomentospora prolificans Corticosteroids, Immunosupression, Cancer Other (Multiple Myeloma), Hematopoietic stem cell transplantation (HSCT) - Autologous, Chemotherapy Eyes Amphotericin B lipid complex Left vitrectomy Unknown No 2014
Lomentospora prolificans Corticosteroids, Immunosupression, Chronic pulmonary disease, Solid organ transplantation Lungs Voriconazole, Micafungin Other Complete Response Yes 2017
Lomentospora prolificans Chronic pulmonary disease, Diabetes mellitus Lungs Voriconazole Stable Disease Yes 2015
Lomentospora prolificans Other: Chronic granulomatous disease and PICC line Blood Micafungin Voriconazole, Other Complete Response Yes 2017
Lomentospora prolificans Major surgery Bones, Skin and Deep soft tissues, Disseminated Fluconazole, Micafungin, Amphotericin B liposomal Voriconazole, Posaconazole, Other Numerous debridements Stable Disease No 2014
Lomentospora prolificans Corticosteroids, Immunosupression, Cancer (Lymphoma), Chemotherapy, Neutropenia Blood, CNS, Liver, Lungs, Spleen, Disseminated Amphotericin B liposomal, Voriconazole, Micafungin, Amphotericin B deoxycholate, Posaconazole Progression No 2017
Scedosporium apiospermum Corticosteroids, Chronic liver disease, Chronic pulmonary disease CNS Liposomal amphotericin B, Posaconazole solution Liposomal amphotericin B, Posaconazole Deterioration or failure No 2007
Scedosporium apiospermum Chronic liver disease, Chronic pulmonary disease, Diabetes mellitus Lungs Voriconazole Voriconazole, Amphotericin B deoxycholate Deterioration or failure No 2007
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany