Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Culture available Scedosporium apiospermum ICU Paranasal sinus(es) Left sphenoid and ethmoid sinustomy Unknown Yes 2008
Lomentospora prolificans Major surgery Bones, Skin, Deep soft tissues, Disseminated Fluconazole, Micafungin, Liposomal amphotericin B Voriconazole, Posaconazole, Terbinafine Numerous debridements Stable Disease No 2014
Lomentospora prolificans No risk factor identified Blood Micafungin Voriconazole, Terbinafine Complete Response Yes 2017
Scedosporium apiospermum No risk factor identified Lungs Itraconazole Itraconazole Bisegmentectomy seg 1+2 Complete Response Yes 2017
Lomentospora prolificans Corticosteroids, Immunosuppression, Chronic pulmonary disease, Solid organ transplantation Lungs Voriconazole, Micafungin Terbinafiine Unknown Yes 2017
Lomentospora prolificans Cancer Other (Multiple Myeloma), Corticosteroids, Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT) Eyes Amphotericin B lipid complex Left vitrectomy Unknown No 2014
Lomentospora prolificans Cancer (Lymphoma), Corticosteroids, Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT), Neutropenia Blood Fluconazole, Micafungin Liposomal amphotericin B Unknown No 2015
Lomentospora prolificans Chronic cardiovascular disease Eyes Fluconazole, Voriconazole Terbinafiine, Micafungin, Voriconazole Left eye enucliation Unknown Yes 2015
Lomentospora prolificans Cancer (AML), Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT) Blood, Disseminated Caspofungin Deterioration or failure No 2016
Scedosporium apiospermum Cancer (AML), Corticosteroids, Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT) Lungs Caspofungin, Liposomal amphotericin B Voriconazole Keilresektion lunge links Stable Disease No 2016
Scedosporium boydii Cancer Other (Acute Leukemia), Corticosteroids, Immunosuppression, Alcoholism, Chemotherapy, Chronic liver disease, Major surgery, Neutropenia, ICU Kidneys, Liver, Lungs, Spleen, Epididymis, Disseminated Liposomal amphotericin B, Caspofungin, Voriconazole Deterioration or failure No 2016
Lomentospora prolificans Cancer (AML), Corticosteroids, Immunosuppression, Chemotherapy, Neutropenia Blood, Lung and Skin infektion was suspected, but no attempt for culture/histo because of palliative Situation, Disseminated Liposomal amphotericin B Deterioration or failure No 2017
Scedosporium apiospermum Corticosteroids, Immunosuppression, Diabetes mellitus, Solid organ transplantation CNS, Deep soft tissues, Disseminated Voriconazole Unknown No 2010
Scedosporium apiospermum Corticosteroids, Immunosuppression, Chronic cardiovascular disease, Chronic pulmonary disease, Diabetes mellitus Deep soft tissues Voriconazole Complete Response Yes 2005
Scedosporium apiospermum Corticosteroids, Immunosuppression, Chronic renal disease Lungs Voriconazole Voriconazole Complete Response Yes 2011
Scedosporium apiospermum No risk factor identified Deep soft tissues Voriconazole, Amphotericin B deoxycholate Voriconazole Complete Response Yes 2014
Scedosporium apiospermum Immunosuppression Deep soft tissues, Lip, finger and right parotid gland, Disseminated Voriconazole Complete Response No 2014
Scedosporium spp. Corticosteroids Bones, Paranasal sinus(es) Right limited endoscopic sinus surgery and drainage of frontal sinusitis with a right maxillary antrostomy and right anterior and posterior ethmoidectomy Unknown Yes 2014
Scedosporium apiospermum Cancer (Lymphoma), Immunosuppression, Chemotherapy, Hematopoietic stem cell transplantation (HSCT), Neutropenia, ICU Lungs Posaconazole Deterioration or failure No 2000
Scedosporium apiospermum complex No risk factor identified Paranasal sinus(es) Functional Endoscopic Sinus Surgery (FESS) of right side sinus Unknown Yes 2016
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany