Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Lomentospora prolificans Chemotherapy, Neutropenia Blood, Disseminated Amphotericin B liposomal Amphotericin B liposomal - Progression No 2017
Culture available Lomentospora prolificans Chemotherapy, Neutropenia Blood, CNS, Eye, Disseminated Amphotericin B liposomal Amphotericin B liposomal vitrectomy of the right eye Progression No 2016
Culture available Lomentospora prolificans HSCT, ICU Kidneys, Lungs, Myocardium Caspofungin Voriconazole, Terbinafine - Deterioration or failure No 2008
Lomentospora prolificans ICU, Major surgery Lungs, Peritoneum, Skin Fluconazole Voriconazole, Caspofungin, Liposomal amphotericin B - Deterioration or failure No 2008
Lomentospora prolificans No risk factors Eye Fluconazole, Voriconazole, Amphotericin B deoxycholate Fluconazole, Voriconazole, Amphotericin B deoxycholate Enucleation of the left eye Complete Response Yes 2016
Lomentospora prolificans Chemotherapy, ICU, Neutropenia Blood Itraconazole - - Deterioration or failure No 2015
Culture available Lomentospora prolificans ICU Paranasal sinus(es) - Itraconazole Surgical debridement of sinus nasalis Complete Response Yes 2006
Lomentospora prolificans Trauma Bone, Joint - - Extense debridement for cleaning, with medium arthrotomy Complete Response Yes 2014
Lomentospora prolificans Chemotherapy, Neutropenia, ICU Gastrointestinal tract, Kidneys, Disseminated - - - Progression No 2015
Lomentospora prolificans Chemotherapy, Neutropenia Blood, CNS, Eye, Disseminated - - - Unknown No 2016
Culture available Pseudallescheria boydii ICU Paranasal sinus(es) - - Nasal Endoscopy left, Mucoid and caseous material removed from nasal cavity Unknown Yes 2012
Scedosporium apiospermum No risk factors CNS, Paranasal sinuses Amphotericin B lipid complex Amphotericin B lipid complex Cerebral abscess drainage Progression No 2016
Scedosporium apiospermum Chronic liver disease, Chronic pulmonary disease CNS Amphotericin B liposomal, Posaconazole, Voriconazole Amphotericin B liposomal, Posaconazole, Voriconazole Cerebal pus drainage Unknown No 2010
Scedosporium apiospermum Chemotherapy, ICU, Neutropenia Lungs Caspofungin Voriconazole, Terbinafine - Deterioration or failure No 2011
Scedosporium apiospermum Chemotherapy, HSCT-Allogeneic Lung Caspofungin, Amphotericin B liposomal Caspofungin, Amphotericin B liposomal Wedge resection of left lung Stable Disease No 2016
Scedosporium apiospermum ICU Lung Fluconazole Fluconazole - Complete Response Yes 2012
Culture available Scedosporium apiospermum ICU, Polymyalgia rheumatica Eyes Itraconazole, Amphotericin B deoxycholate, Ofloxacin eye drops Voriconazole - Partial Response Yes 2011
Scedosporium apiospermum Chronic pulmonary disease, ICU, Cystic fibrosis Lungs Itraconazole, Caspofungin, Voriconazole Voriconazole, Liposomal amphotericin B - Unknown Yes 2011
Scedosporium apiospermum Chronic liver disease, Chronic pulmonary disease, ICU CNS Liposomal amphotericin B, Posaconazole Liposomal amphotericin B, Posaconazole - Deterioration or failure No 2007
Scedosporium apiospermum Chronic liver disease, Chronic pulmonary disease, Diabetes mellitus, ICU Lungs Voriconazole Voriconazole, Amphotericin B deoxycholate - Deterioration or failure No 2007
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany