Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Last Observed
Culture available Fusarium incarnatum Diabetes mellitus, ICU Deep soft tissues, Skin, Synovialis Liposomal amphotericin B Unknown Yes 2009
Culture available Fusarium oxysporum Chronic pulmonary disease, Diabetes mellitus, ICU Lungs Voriconazole Partial Response Yes 2009
Culture available Fusarium sp. Diabetes mellitus, ICU Deep soft tissues surgical debridement Unknown Yes 2007
Fusarium sp. Chemotherapy, Diabetes mellitus, ICU, Other: AML (Relapse) Blood Voriconazole Voriconazole Complete Response Yes 2010
Fusarium sp. Chemotherapy, ICU, Neutropenia, Other: AML Blood, Skin, No diagnostic procedures could be carried out to prove/rule out the presence of pulmonary and hepatic fungal disease Voriconazole Voriconazole Complete Response Yes 2010
Culture available Fusarium proliferatum ICU, No risk factor identified Deep soft tissues Fluconazole Excision Partial Response Yes 2009
Culture available Fusarium sp. ICU, Trauma Deep soft tissues Voriconazole Stable Disease No 2007
Culture available Fusarium oxysporum Chronic pulmonary disease, ICU, Limbal stem cell transplantation (treated with cyclosporine and steroids) Eyes Itraconazole Voriconazole, Caspofungin, Posaconazole solution Partial Response Yes 2010
Fusarium proliferatum HSCT, ICU Liver, Lungs, Skin, nail Amphotericin B deoxycholate, Voriconazole, Itraconazole, Posaconazole solution Deterioration or failure No 2007
Culture available Fusarium sp. Diabetes mellitus, HSCT, ICU, Other: prolonged neutropenia ~ 3 months Blood, Lungs, Paranasal sinus(es), Skin Amphotericin B lipid complex, Voriconazole Posaconazole solution Bilateral nasal endoscopy with endoscopic resection of invasive fungal rhinosinusitis. Deterioration or failure No 2008
Culture available Fusarium incarnatum ICU, SOT Bones, Deep soft tissues Amphotericin B deoxycholate, Voriconazole amputation Partial Response Yes 2007
Culture available Fusarium sp. Chronic renal disease, HSCT, ICU, SOT Blood, Paranasal sinus(es), Skin Fluconazole, Caspofungin, Voriconazole Amphotericin B lipid complex, Caspofungin, Voriconazole ENDOSCOPIC SINUS SURGERY AND DÉBRIDEMENT OF THE NASAL CAVITIES BILATERALLY, MEDIAL MAXILLECTOMY BIL Deterioration or failure No 2006
Culture available Fusarium proliferatum Chemotherapy, ICU, Neutropenia Blood, Deep soft tissues, Skin, Spleen Caspofungin, Amphotericin B lipid complex Posaconazole solution, Amphotericin B lipid complex, Voriconazole Partial Response Yes 2008
Fusarium sp. Chemotherapy, ICU, Neutropenia Blood, Lungs, Skin Voriconazole, Caspofungin Deterioration or failure No 2006
Fusarium sp. Chemotherapy, ICU, Neutropenia Blood, Skin Voriconazole Deterioration or failure No 2006
Fusarium sp. Chemotherapy, ICU, Neutropenia Blood, Lungs, Skin Voriconazole, Caspofungin Excision of pulmonary lesions Complete Response Yes 2010
Fusarium sp. Chemotherapy, ICU, Neutropenia Skin Amphotericin B deoxycholate, Caspofungin Voriconazole Complete Response Yes 2008
Fusarium oxysporum Chemotherapy, HSCT, ICU, Neutropenia Blood Liposomal amphotericin B, Voriconazole Complete Response Yes 2010
Fusarium sporotrichioides Chemotherapy, ICU, Neutropenia Lungs Caspofungin Voriconazole Complete Response Yes 2011
Fusarium sp. Chemotherapy, ICU, Neutropenia Blood, Lungs, Skin Posaconazole solution, Liposomal amphotericin B Voriconazole, Liposomal amphotericin B, Posaconazole solution Partial Response Yes 2011
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany